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KMID : 1094020140310030163
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Journal of Veterinary Clinics
2014 Volume.31 No. 3 p.163 ~ p.169
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Decreased Insulin Secretion in Dogs with Chronic Mitral Valve Insufficiency
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Kang Jong-il
Lee Seung-Gon
Park Seong-Jun
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Abstract
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Glucose metabolism abnormalities secondary to heart failure, including insulin resistance (IR) and impairedfasting glucose, have been gradually recognized as important prognostic factors in disease progression. However, todate, no study has investigated glucose abnormalities in dogs with chronic mitral valve insufficiency (CMVD). Thus,we hypothesized that glucose metabolism abnormalities due to heart failure may develop in dogs with CMVD. Aprospective study was performed on 113 client-owned dogs with variable CMVD severities. Serum insulin, glucagon,fructosamine, and glucose concentrations were measured, and insulin resistance was determined using the homeostaticmodel assessment (HOMA) score. The serum insulin concentration had a significant inverse association with the heartfailure severity. However, there was no significant association between the heart failure severity and fructosamine,HOMA score, and fasting blood glucose. Insulin, fructosamine, and HOMA had a significant positive association withbody condition scores (BCS), whereas glucose had no association. This study found that insulin secretion in dogswith naturally occurring heart failure due to CMVD might be compromised as the disease worsens.
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KEYWORD
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insulin resistance, impaired fasting glucose, heart failure
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